Changes in version 1.4.3 (2021-09-21) Example in efficacySquaredError function adjusted. Changes in version 1.4.2 Authors adjusted and doi added to DESCRIPTION. Dontrun changed to donttest. Rm(list = ls()) removed from all scripts. Examples using population methods removed. Changes in version 1.4.1 repeatCount parameter in vignettes decreased to 50 to reduce package build time. LICENSE file removed from the top directory; its contents moved to LICENSE.note file. Population mnethods removed from examples. Changes in version 1.4.0 epiR package dependency removed (WaldCI function updated). DESCRIPTION updated, example into README added, LICENSE and LICENSE.note files added, copyright added, documentation and vignettes updated. Changes in version 1.3.0 Naming convention updated (control, diseased, nondiseased, casecount, PoDBAY) both in code and documentation Changes in version 1.2.4 Unit tests created, cppMLE corrected, ImmunogenicitySubset - methodology changed, documentation & DESCRIPTION adjusted to CRAN standards Changes in version 1.2.3 PODBA-19 - new functions documentation, package data added, vignettes created, warning and error messages added, bimodal functions removed Changes in version 1.2.2 PODBA-34 - cppPoD function adjusted for adjustTiters, implemented into cppMLE and PoDMLE Changes in version 1.2.1 PODBA-28 - efficacyComputation function adjusted, Dengue and Zostavax functions removed from the package Changes in version 1.2 PODBA-11 - cleaning of the code - Incidence rate, confidence intervals, unused variables and functions Changes in version 1.1.1 PODBA-16 - formatting adjustments in PoDParamEstimation Changes in version 1.1 PODBA-13 - New bootstrapping, new Immunogenicity sample creation (three methods = Full, Ratio, Fixed), PoD curve point estimation Changes in version 1.0 Initial version of the package